Endocrine Abstracts

Objective: i) To evaluate plasma levels of IL6, adiponectin and resistin in subjects with diabetic foot in comparison with subjects without foot complications. ii) To assess the impact of vitamin D status on the levels of above inflammatory markers.Methods: A total 100 diabetic foot cases and 100 diabetic controls were recruited in the study. Serum level of 25OH vitamin D was estimated from the cases & controls by RIA. Serum IL6, adiponectin and resi...

Objectives: i) To measure olfactory bulbs and sulci using dedicated magnetic resonance imaging (MRI) sequences in idiopathic isolated hypogonadotropic hypogonadism (IHH) patients with a well detailed phenotype characterization and ii) to correlate MRI findings with a clinical smell test.Methods: MRI was performed in 20 patients (all male, aged between 11 and 45 years, mean age of 26) with IHH and olfactory dysfunction was assessed using the smell identif...

Objectives: To determine and compare inflammatory markers including adiponectin, visfatin and IL18 in patients with polycystic ovarian syndrome (PCOS) 2. To find out whether adiponectin and interleukin 18 (IL18) is associated with markers of insulin resistance, hyperandrogenism and carotid intima-media wall thickness (CIMT) as a cardiovascular risk factor.Methods: This is a prospective controlled study involving 60 consecutive euglycemic patients with PC...

Objective: To investigate vitamin D status in patients with autoimmune hypothyroidism.Methods: The study group consisted of 100 patients with newly diagnosed Hashimato’s thyroiditis and 100 subjects as the control group. Parameters of calcium metabolism, thyroid function tests and 25(OH) vitamin D levels were measured.Results or Case Presentation: Mean age of the study study groups was 33.4±4.8 years with female:male=72:2...

An 82-year-old lady admitted after multiple episodes of collapse and her blood sugar levels were noted to be less than 2.0 mmol/l. A supervised controlled fasting test was performed and results were consistent with Insulinoma. Imaging revealed a mass in the tail of the pancreas with metastasis to the liver. Liver biopsy confirmed the diagnosis of a poorly differentiated neuroendocrine tumour. She continued to have hypoglycaemic episodes which were difficult to manage. Dietary ...

32 year old female with no prior past medical problems presented to hospital with a two week history of rapid onset delusional psychosis with religious themes, paranoid ideas and rapidly developing into catatonia. There was no previous history of psychiatric disorders. On physical examination the Glasgow Coma Score (GCS) was 15 and she was responding to visual hallucinations; speaking to imaginary person and reported seeing objects. She was afebrile and bedside observations we...

68 years old female initially referred to endocrine clinic in November 2016 for assessment of fluctuating thyroid function. She had a history of long standing primary hypothyroidism, stable on treatment with 100 mcg Levothyroxine. In last one year, Levothyroxine was tapered and stopped due to persistent suppression of TSH and high normal Free T4. Last tests showed TSH of <0.01mIU/l and Free T4 of 27.1 pmol/l. She had ongoing complaints of feeling increasingly tired and gen...

A 36 year old female patient presented to the emergency department with a generalised tonic-clonic seizure. She had a past medical history of epilepsy and tuberous sclerosis. Her medication prior to hospital admission was Tegretol which had controlled her seizures well for many years. On admission, the adjusted calcium level was 1.4 mmol/l with a raised ALP 508 U/l and a phosphate within the normal reference range at 1.1 mmol/l. Magnesium was also within the normal reference r...

Introduction: PATRO children is an international, non-interventional, longitudinal study of the long-term safety of a biosimilar recombinant human growth hormone (Omnitrope, Sandoz). In particular, the study assesses the diabetogenic potential of Omnitrope and the risk of malignancies. The long-term efficacy is a secondary objective of the study. Here we present safety and efficacy data of UK patients recruited since 2008, following an interim analysis in May 2017.<p class...

Background: Old age is proven to be one of the greatest danger factors for intensively dealing with COVID-19 patients. Stoutness and diabetes are enhancers of dangers among COVID-19 patients. In any case, there exists restricted proof for the modifiable danger components, for example, bodyweight which is an indicator of the Intensive Care Unit and its need among type 2 diabetes patients. In this review, the subject of body weight as an indicator of ICU confirmations will be in...